Human CMV: Cytomegalovirus infects a wide variety of species of animal. Cytomegalovirus is a member of the genera of beta-herpesvirinae. Beta-herpesvirinae is a subfamily belonging to herpesvirinae. The Beta-herpesvirinae contains roseolovirus, second genus, which comprises of HHV-6B, HHV-6A, and HHV-7.
The members of this family are connected to their organization and gene content. They all exhibit a constrained long replication cycles and host range. Cytomegalovirus’s are been recognized that it infect a variety of host species. It includes non-human rodents and primates and human. These viruses infecting a variety of species share some common genes.
However, they also contain some genes which are exceptional to the virus which infect the specific host species. The host area of these kinds of viruses is limited. For an example: A human virus does not infect a rodent and a rodent virus does not infect a human.
HCMV does not exist as a defined virus genomic, but as a range of different strains. A number of studies of HCMV have investigated the importance of viral genotypes for the course of Human Cytomegalovirus infection. In re-infection, the individual may get additional infections, and strains with a combination of strains. The study of such assorted infections has turned out to be increasingly significant. It is significant not only for examining the implications of mixed genomic infections. It is also important for knowing the pathogenesis of successive re-infections with HCMV strain. The study is also important for vaccine development of HCMV and focus on mixed Human CMV strains.
Human Cytomegalovirus is a typical kind of virus. Human CMV 235,000 genomes hold more than two hundred ORF’s likely to code proteins, which are preserved in the 5 isolates of CMV that has been sequenced. A genomic type of map of Human Cytomegalovirus clinical isolate can be referred. Most of the ORFs have not been revealed to encode proteins. However, the FIX ORF’s are also found in TR, Toledo, and PH strains of the Cytomegalovirus. After cultured fibroblasts infection, the viral ORF’s are uttered in a highly regulated and organized cascade of L, E, and IE transcription.
Human CMV spreads by means of many cell types in the host, who is infected. In other type of cells, it enters latency by becoming quiescent. Human Cytomegalovirus does not make a universal shut down of mRNA accumulation. Relatively, it expresses its mRNA as the mass cell continues to process and synthesize its own mRNA’s.
For Human Cytomegalovirus studies, genomic technologies are very useful. Genomic technologies are very helpful in the analysis of HCMV. These technologies are also helped in the detection of complexity of interaction and viral genome. The ability of continuously monitoring the accumulation and growth of host cell and all viruses can provide a detailed view of the relations of HCMV with a variety of host cells.
The function of genomic technologies to pathogen-infected organisms and cells is still not fancy. However, genomic studies have commenced to provide new insights towards the interaction of pathogen host cell.